We present a rationally designed, self-assembled nanochip capable of capturing a target protein by means of pre-selected binding sites. We show how the confined peptides are capable of specifically capturing β2m from the surface–liquid interface with micromolar affinity, hence providing a viable proof-of-concept for our approach to peptide design

 

A. Feyisara Adedeji Olulana, M.A. Soler, M. Lotteri, H. Vondracek, L. Casalis, D. Marasco, M. Castronovo, S. Fortuna
Computational Evolution of Beta-2-Microglobulin Binding Peptides for Nanopatterned Surface Sensors
Int. J. Mol. Sci., 2021, 22(2), 812.