Our commitment in the development of new computational protocols that can compete and, in time, eliminate the demand for in vivo procedures for antibody discovery and maturation has been prized once again with a 40,000$ grant with the project ” De-novo engineered antibody fragments: validation of the first in-silico pipeline for antibody discovery ” from the Alternatives Research & Development Foundation (ARDF). We thank Barbara Medagli, developing the method for the expression and characterization of computational designed antibody fragments, for her participation as Co-PI of this project.