WE ARE HIRING!!! We are looking for two postdoctoral researchers: a biologist and a computational chemist/biophysicist to join us reaching the goal of our new AIRC project. Please follow THIS LINK for further details on each position.
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UniTS press release on our latest AIRC project
The University of Trieste celebrated our achievements HERE (post available only in Italian), and also on FACEBOOK and LinkedIn!
Read our latest paper on in silico designed peptides for nanopatterned surface sensors!
We present a rationally designed, self-assembled nanochip capable of capturing a target protein by means of pre-selected binding sites. We show how the confined peptides are capable of specifically capturing β2m from the surface–liquid interface with micromolar affinity, hence providing a viable proof-of-concept for our approach to peptide design A. Feyisara Adedeji Olulana, M.A. […]
We have been awarded an “Investigator Grant” from the Italian Association for Cancer Research (AIRC)
Our team has just been awarded an AIRC IG 2020 grant with the title “Computational design of theragnostic nanobodies: targeting missense mutants in metastatic breast cancer cells” (409,000€ – 5 years).
We are part of the H2020-MSCA-ITN team INTERfaces!
We are part of the team being awarded the H2020 Marie Skłodowska-Curie Actions (MSCA) Innovative Training Networks (ITN) – European Industrial Doctorates (EID) with the project “INTERfaces – Heterogeneous biocatalysis reaction cascades training network” INTERfaces combines material science and protein engineering to design tailored enzymes and (bio-based) materials that will complement each other to obtain […]
We welcome Nikola Minovski in our team!
Welcome to Nikola Minovski, who joined today our team to work on the project “In silico design of customised high-affinity antibody fragments for biomarker detection” from the Alternatives Research & Development Foundation (ARDF).
In press on ACS Med. Chem. Lett.!
We have identified a strong diazepane based σR ligand with high affinity, low cytotoxicity, and excellent antioxidant profile. For further details, read our paper here: D. Zampieri, S. Fortuna, A. Calabretti, M. Romano, R. Menegazzi, D. Schepmann, B. Wünsch, M.G. Mamolo Synthesis, Cytotoxicity Evaluation and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands ACS Med. Chem. […]
Just accepted in Chemical Communications!!!
Our paper “A consensus protocol for the in silico optimisation of antibody fragments” has just been accepted for publications, marking the first milestone of our AIRC project “Computational design of customised nanobodies for oncology applications: prognostic candidates for HER2 as first case”. In this paper we present BINDesignER: our in silico mutagenetic protocol for the […]
Welcome to Hendrik Vondracek, who joined today our AIRC research project.
We welcome Hendrik Vondracek in our team! Hendrik is a physicist and got his PhD in 2018 from the Ruhr-Universität in Bochum (Germany). He then worked on a project involving research-driven (Elettra NanoInnovation Lab) and commercial (Ulisse BioMed) partners for the development of an electrochemical biosensor for the detection of biomarkers, and chose our team […]
We have been awarded a “ARDF’s Annual Open grant” from the Alternatives Research & Development Foundation (ARDF)
Our commitment in the development of new computational protocols that can compete and, in time, eliminate the demand for in vivo procedures for antibody discovery and maturation has been prized with a 40,000$ grant with the project “In silico design of customised high-affinity antibody fragments for biomarker detection” from the Alternatives Research & Development Foundation […]