{"id":1082,"date":"2019-10-29T12:01:18","date_gmt":"2019-10-29T12:01:18","guid":{"rendered":"http:\/\/sites.units.it\/sarafortuna\/?p=1082"},"modified":"2019-10-29T12:05:22","modified_gmt":"2019-10-29T12:05:22","slug":"just-accepted-in-chemical-communications","status":"publish","type":"post","link":"https:\/\/sites.units.it\/sarafortuna\/index.php\/just-accepted-in-chemical-communications\/just-accepted-in-chemical-communications\/","title":{"rendered":"Just accepted in Chemical Communications!!!"},"content":{"rendered":"<p>Our paper &#8220;<a href=\"https:\/\/doi.org\/10.1039\/C9CC06182G\">A consensus protocol for the in silico optimisation of antibody fragments<\/a>&#8221; has just been accepted for publications, marking the first milestone of our <a href=\"http:\/\/sites.units.it\/sarafortuna\/index.php\/sara-fortuna-has-been-awarded-a-my-first-airc-grant-from-the-italian-association-for-cancer-research-airc\/sara-fortuna-has-been-awarded-a-my-first-airc-grant-from-the-italian-association-for-cancer-research-airc\/\">AIRC project<\/a> <em>&#8220;Computational design of customised nanobodies for oncology applications: prognostic candidates for HER2 as first case&#8221;.<\/em><\/p>\n<p>In this paper we present <a href=\"http:\/\/sites.units.it\/sarafortuna\/index.php\/downloads\/\">BINDesignER<\/a>: our in silico mutagenetic protocol for the computational optimisation of single domain antibodies (or nanobodies, VHHs). We show in this paper that, by aplying our optimisation algorithm, we could obtain a VHH mutant with significantly enhanced experimental affinity with respect to the original VHH it matured from. The protocol can be employed as it is for the optimization of peptides, antibody fragments, and (given enough computational power) of larger antibodies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our paper &#8220;A consensus protocol for the in silico optimisation of antibody fragments&#8221; has just been accepted for publications, marking the first milestone of our AIRC project &#8220;Computational design of customised nanobodies for oncology applications: prognostic candidates for HER2 as first case&#8221;. In this paper we present BINDesignER: our in silico mutagenetic protocol for the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":626,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20,12],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.9.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Just accepted in Chemical Communications!!! - SARA (Fortuna) Research Team<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.units.it\/sarafortuna\/index.php\/just-accepted-in-chemical-communications\/just-accepted-in-chemical-communications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Just accepted in Chemical Communications!!! - SARA (Fortuna) Research Team\" \/>\n<meta property=\"og:description\" content=\"Our paper &#8220;A consensus protocol for the in silico optimisation of antibody fragments&#8221; has just been accepted for publications, marking the first milestone of our AIRC project &#8220;Computational design of customised nanobodies for oncology applications: prognostic candidates for HER2 as first case&#8221;. In this paper we present BINDesignER: our in silico mutagenetic protocol for the [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.units.it\/sarafortuna\/index.php\/just-accepted-in-chemical-communications\/just-accepted-in-chemical-communications\/\" \/>\n<meta property=\"og:site_name\" content=\"SARA (Fortuna) Research Team\" \/>\n<meta property=\"article:published_time\" content=\"2019-10-29T12:01:18+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-10-29T12:05:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sites.units.it\/sarafortuna\/wp-content\/uploads\/2016\/11\/fig1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"472\" \/>\n\t<meta property=\"og:image:height\" content=\"294\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.units.it\/sarafortuna\/index.php\/just-accepted-in-chemical-communications\/just-accepted-in-chemical-communications\/\",\"url\":\"https:\/\/sites.units.it\/sarafortuna\/index.php\/just-accepted-in-chemical-communications\/just-accepted-in-chemical-communications\/\",\"name\":\"Just accepted in Chemical Communications!!! - SARA (Fortuna) Research Team\",\"isPartOf\":{\"@id\":\"https:\/\/sites.units.it\/sarafortuna\/#website\"},\"datePublished\":\"2019-10-29T12:01:18+00:00\",\"dateModified\":\"2019-10-29T12:05:22+00:00\",\"author\":{\"@id\":\"https:\/\/sites.units.it\/sarafortuna\/#\/schema\/person\/dbdc6b95bcc06a6cc4f88c44a9622da9\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.units.it\/sarafortuna\/index.php\/just-accepted-in-chemical-communications\/just-accepted-in-chemical-communications\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.units.it\/sarafortuna\/#website\",\"url\":\"https:\/\/sites.units.it\/sarafortuna\/\",\"name\":\"SARA (Fortuna) Research Team\",\"description\":\"Self-Assembly, Recognition, and Applications\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.units.it\/sarafortuna\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/sites.units.it\/sarafortuna\/#\/schema\/person\/dbdc6b95bcc06a6cc4f88c44a9622da9\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/sites.units.it\/sarafortuna\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/feea21a7c7a068d1d51eb249d9c3084d?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/feea21a7c7a068d1d51eb249d9c3084d?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"url\":\"https:\/\/sites.units.it\/sarafortuna\/index.php\/author\/admin\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Just accepted in Chemical Communications!!! - SARA (Fortuna) Research Team","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.units.it\/sarafortuna\/index.php\/just-accepted-in-chemical-communications\/just-accepted-in-chemical-communications\/","og_locale":"en_US","og_type":"article","og_title":"Just accepted in Chemical Communications!!! - SARA (Fortuna) Research Team","og_description":"Our paper &#8220;A consensus protocol for the in silico optimisation of antibody fragments&#8221; has just been accepted for publications, marking the first milestone of our AIRC project &#8220;Computational design of customised nanobodies for oncology applications: prognostic candidates for HER2 as first case&#8221;. 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